Functional neuroscience

🧠 NFB & Chill: Lithium & Alzheimer’s; what the new research really says

👉Book a free consult call: https://calendly.com/drhill1 Recent studies suggest the brain naturally uses tiny amounts of lithium—and that amyloid plaques may sequester it, potentially triggering Alzheimer’s. In this video I break down the proposed mechanisms (GSK‑3β, BACE1, neuroinflammation), why micro‑doses and “plaque‑evasive” formulations (e.g., lithium orotate) showed promise in animal models, what human data suggest so far, and whether lithium looks preventative, therapeutic, or both. Clear takeaways, no hype, and what to watch for in upcoming clinical trials. Studies mentioned: Core new paper (mechanism + LO in mice): Aron L., et al. Lithium deficiency and the onset of Alzheimer’s disease. Nature (2025). https://pubmed.ncbi.nlm.nih.gov/40770094/ Human clinical trials • Nunes M.A., et al. Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer’s disease. Curr Alzheimer Res (2013). https://pubmed.ncbi.nlm.nih.gov/22746245/ • Forlenza O.V., et al. Disease‑modifying properties of long‑term lithium treatment for amnestic MCI (12‑month RCT). Br J Psychiatry (2011). https://pubmed.ncbi.nlm.nih.gov/21525519/ • Forlenza O.V., et al. Clinical and biological effects of long‑term lithium treatment for amnestic MCI (extended follow‑up). Br J Psychiatry (2019). https://pubmed.ncbi.nlm.nih.gov/30947755/ • Damiano R.F., et al. Revisiting global cognitive and functional state 13 years after an RCT of lithium for aMCI. Int Psychogeriatr (2023). https://pubmed.ncbi.nlm.nih.gov/36786725/ (Free full text: https://pmc.ncbi.nlm.nih.gov/articles/PMC9976922/) Preclinical microdose formulations • Wilson E.N., et al. BACE1 inhibition by microdose lithium formulation NP03 rescues memory loss and early amyloid neuropathology. Transl Psychiatry (2017). https://pubmed.ncbi.nlm.nih.gov/28763060/ • Nunes M.A., et al. Chronic microdose lithium prevented memory loss in a transgenic AD model. J Alzheimers Dis (2015). https://pubmed.ncbi.nlm.nih.gov/26605788/ Population data (context) • Kessing L.V., et al. Association of lithium in drinking water with incidence of dementia (Denmark). JAMA Psychiatry (2017). https://pubmed.ncbi.nlm.nih.gov/28832877/ • Velosa J., et al. Risk of dementia in bipolar disorder and lithium’s protective association (meta‑analysis). Acta Psychiatr Scand (2020). https://pubmed.ncbi.nlm.nih.gov/31954065/ Review on use in psych conditions, in r"low dose", compared to typical psych interventions https://www.psychiatrictimes.com/view/low-dose-lithium-a-new-frontier-in-mental-health-treatment -- Note: Educational only. Not medical advice. Don’t start lithium without talking to your clinician. If this is helpful, please like, subscribe, and share. Questions? Drop them in the comments—I read them all. #Alzheimers #Lithium #BrainHealth #Neuroscience #DementiaResearch ⏰ Live 6 PM Pacific Mondays Subscribe and hit the bell for weekly brain health updates! CONNECT: 💬 Chat with us live during the stream 📧 Questions? Drop them in the comments 🔔 Turn on notifications for upcoming streams 🧠 RESOURCES 🧠 👉Book a free consult call: https://calendly.com/drhill1 👉$250 off QEEG Brain Mapping at Peak Brain: https://peakbraininstitute.com/special/ 💡Whether you're a biohacking enthusiast, longevity seeker, or just curious about optimizing your health, this episode packs actionable insights backed by the latest research . neurofeedback, brain health, anti-aging, meditation, biological age, cognitive decline, longevity, brain training, EEG, mindfulness, digital technology seniors, music therapy, nature therapy, Harvard meditation study, neuroscience, brain optimization, live stream, Dr Hill, chill stream, relaxing educational content, 2025 research, cognitive function, memory improvement, stress reduction, healthy aging