Health coach, author and nutrition entrepreneur, Wendi Michelle discusses optimizing health, nurishing our bodies, healing ourselves, reversing her late stage lyme disease, cryotherapy, neurofeedback training, and the “brain cocktail.” Wendi Michelle is the VP of Operations and Executive Director of Wellness at Next Health, which is one of the premier health and wellness centers in Los Angeles. She is also a nutrition entrepreneur as the founder and creator of food startups Hoola Bars and Hummish. Wendi is also a long-time health coach, biohacker, personal trainer, and author of Effortless Real Foods. Wendi has dedicated her life to giving people tools to master their own nutrition, fitness and health goals. A life altering face to face confrontation with her own health set her on a path to disrupt every system that opposes complete health and wellbeing in order to empower people in truth. Wendi continues to seek out and apply the latest in scientific advancements believing that we have barely scratched the surface of human potential.
Episode Summary
On a recent episode of Head First, I talked with a health coach, author, and nutrition entrepreneur who built her career around giving people more agency over their own health. She runs operations at a Los Angeles wellness center, founded two food companies, wrote a book on real-food eating, and reversed her own late-stage neurological Lyme disease. The conversation kept circling back to one idea I work in every day at Peak Brain: how to give people data and tools without overselling certainty. Here is what we covered, and where the neuroscience actually holds up.
What does it mean to work at the edge of what's known?
My guest and I work in the same uncomfortable space. She runs metabolic panels, genetic tests, and body composition scans. I run QEEG brain maps. Both of us hand people data about their bodies and brains, and both of us have to resist the urge to over-read it.
A QEEG pattern might suggest something. A homocysteine level might suggest something. The honest move is to say "this is interesting, here is one plausible interpretation," and then stop. Cholesterol numbers, cortisol numbers, EEG band ratios all carry conflicting literatures. When you pretend a marker is deterministic, you mislead the person in front of you.
She raised a point I see constantly in the clinic. The placebo effect runs in reverse. If you tell a client their labs look frightening, or you load a brain map with doom, you can trigger a nocebo response that sends them into a negative spiral. The data-sharing itself becomes part of the intervention. I would rather let someone sit with an unknown than hand them a conclusion they will ruminate on at 3am.
Why does cryotherapy seem to improve sleep?
Whole-body cryotherapy exposes you to roughly negative 165 degrees Fahrenheit for a few minutes. The reliable, well-documented effect is reduced pain and inflammation. The interesting clinical observation, and this is observation rather than established mechanism, is that people report some of the deepest sleep they have had in years afterward.
Here is a plausible mechanism. Acute cold triggers vasoconstriction and a systemic stress and immune response. The body gets a strong signal that something needs attention. When the person then gets home and rests, the repair machinery that normally only runs hard when you are fighting a cold or flu gets a window to work. That is extrapolation, not proven causation. The inflammation reduction is real and measurable. The sleep benefit is consistent enough across people to take seriously, even without a clean mechanistic story. If sleep is your target, there are more direct levers worth pulling first, which I cover in biohacking sleep.
Does IV nutrient therapy actually do anything?
IV vitamin therapy delivers high-dose nutrients directly into the bloodstream, bypassing the gut. The case for it is straightforward. Oral supplements and food both go through first-pass metabolism, so the concentration that reaches your cells is a fraction of what you swallowed. Anyone with compromised gut absorption is leaving even more on the table. Bypassing digestion gets serum levels up that you cannot reach by eating.
The standard base is a Myers cocktail: vitamin C, magnesium, calcium, the B vitamins, and trace minerals. The "brain cocktail" she described builds on that base with targeted additions:
- Acetyl-L-carnitine for mitochondrial fuel and energy metabolism
- Glycine, an inhibitory amino acid neurotransmitter
- GABA, the primary inhibitory neurotransmitter
- Glutamine, a precursor to glutamate
- Taurine, which supports inhibitory tone
- Zinc, for immune and enzymatic pathways
The logic is precursor and substrate delivery, getting around rate-limiting conversion steps so the brain has the raw materials it needs. Whether a given person feels anything from an IV is a poor measure of whether it did anything. Most of what these molecules do happens below the threshold of conscious sensation. The honest framing is that this supplies substrate, not that it produces a guaranteed subjective effect.
What did neurofeedback training actually change?
This is where the conversation got specific, because my guest trained at Peak Brain and described her own results in detail. I want to walk through what happened and the circuit logic behind it.
Her early sessions surfaced emotion she had not felt in a long time. She described becoming numb, with her life moving so fast that the ups and downs had flattened out. After one session she felt anger, and realized she could not remember the last time she had felt angry. Flat affect is not health. Recovering access to a normal emotional range is often the first sign that something is shifting.
A few sessions later she had a day she wanted to bottle. Deeply relaxed in the body, no muscle tension, no jitter, and at the same time the most productive day she could remember. She had assumed peak focus required being wound up or chemically driven. The opposite turned out to be true.
That was left-side training. Here is the mechanism. Left-side neurofeedback generally improves the alerting and tonic activation side of attention. It reduces errors of omission, the moments where your attention simply drops offline and you miss things. When that system comes up, sustained attention gets easier without the cost of feeling revved.
Right-side training does something different. It tends to increase self-control and reduce reactivity. You become less likely to fire off impulsively. With most clients, including her, we train both sides and adjust as the maps change. This is closely related to SMR training, which strengthens the same thalamocortical circuits that produce sleep spindles, which is part of why focus training and sleep improvements often travel together.
Neurofeedback works through operant conditioning that runs below conscious awareness. The feedback rewards the brain when it produces target patterns and dims when it drifts. The brain learns the pattern the way any skill gets learned, through repetition, without a verbal explanation of the goal. This is also why dosing matters. She noticed that when several busy months kept her out of the chair, she only realized how much the training had been helping once it was gone. We had not done quite enough repetition to make the change fully self-sustaining. You pick a protocol, run enough of it to build a durable effect, and only then shift gears. We also pushed her left-side training a little too far at one point and made her wired, then pulled back. That correction is part of working in a space where you balance what is known against what you intuit. For the broader research picture, see is neurofeedback legitimate and the work on neuroplasticity.
Why is fasting more than a "skip a meal" trick?
When she cannot eat something clean, she fasts rather than reach for processed food. Working in the food industry, she knows what ends up in the ingredients list, and she would rather give the body a window to clean itself up than feed it junk.
The metabolic case for fasting is stronger than most people realize. I mentioned a finding that even a 24-hour fast can prompt non-beta islet cells in the pancreas to convert into insulin-producing beta cells, including in insulin-dependent diabetics. That challenges the assumption that those cells are permanently lost. The broader principle is that fasting triggers cellular cleanup and metabolic flexibility, and I cover the practical structure in strategic fasting.
She also makes a behavioral point worth keeping. The all-or-nothing trap, where one bad meal "ruins the day" so you might as well eat poorly until midnight, is a cognitive distortion that sabotages adherence. Flexibility beats rigid rules you cannot sustain. That maps directly onto how habits actually stick.
How should you think about nootropics and side effects?
I am skeptical of most of the nootropic market, and I helped create a basic, vetted supplement stack years ago precisely because I could not figure out from the marketing what was likely to work, what was smart, and what was safe. By the strict definition, a nootropic improves cognition without side effects, which rules out most products carrying the label.
Modafinil is the clearest example. It carries real risk for people who do not have a clinical indication for it. I took prescribed modafinil years ago, a single morning dose for 21 days. On day 21 I woke covered in hives and spent six weeks fighting a massive histamine response, multiple ER and urgent care visits, skin sloughing, caught just before it crossed into Stevens-Johnson syndrome. Unless you have narcolepsy, shift-work sleep disruption, or another genuine sleep disorder, modafinil belongs near the bottom of a biohacking stack, not the top.
The cost-benefit logic that matters most goes like this. If you are healthy and trying to push performance above baseline, your tolerance for side effects should be zero. A small improvement in an already-healthy system is felt subjectively as a large gain, so there is no reason to accept downside risk to get it. Side effects only earn their place when you are repairing a real deficit or illness, where you may have to tolerate some cost on the way to healing. This is the framing I bring to biohacking intelligence and to anyone chasing flow and peak performance.
The through-line: fitness, not fixing
The unifying idea across the whole conversation is a shift from an illness-and-fix model to a fitness model, where you have control, responsibility, and the ability to change your body and brain. My guest sees this most often as a mindset rather than an age group, though it clusters in people who have watched a family member go through the conventional system and want other options on the table.
Genetic testing, body composition scans, brain maps, metabolic panels all serve the same purpose when done right. They give a person the chance to sit with their own data, draw their own conclusions, and make a decision for themselves. That act, choosing for yourself rather than outsourcing the answer to a search engine, is one of the more powerful things you can hand someone.
If you want a place to start, pick one measurable system and one tool. Train left-side attention if you go offline and miss things. Train right-side control if you are reactive. Use a 24-hour fast to test your metabolic flexibility. Add cryotherapy if pain and sleep are your targets. Track what changes, and resist the urge to over-interpret a single number.