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Brain Mapping: What Happens To Your Brain On A “Limitless” Pill…

I got my brain mapped 🧠 Then took a nootropic and did it again a day later, and the results blew me away. It’s one thing to feel more mentally and cognitively sharp, but it’s a whole new story to have data showing the difference in brain activity. By the way, brain mapping can be a really neat tool for you to quantify how your brain may be getting in the way of your peak performance, whether it’s sleep issues, depression, ADHD, anxiety, some form of addiction or even PTSD. I recently visited Peak Brain Institute in LA for an interesting biohacking experiment — I wanted to know how a nootropic, “a limitless pill”, changed my baseline brain activity. Not only did I learn about both the ups and downs, but what’s even cooler, now I finally have quantified evidence how quickly, way above average, my brain processes information. All those brain hacks must be working 🧠 🤓 I’m super grateful for Dr. Andrew Hill, functional neuroscientist coach and founder of Peak Brain Institute, for taking the time to go over my brain and teach me how to make sense of it all. Thank you! The nootropic I tested was the Blue Cannatine from Troscriptions

Episode Summary

A guest came to Peak Brain Institute for an experiment I had not run quite this way before. She wanted to map her brain twice, one day apart, with a single variable changed between the two recordings: a nootropic. This conversation originally aired on Klaudia Balogh's channel, and you can watch the original conversation. What follows is my reading of the data, written in my own voice.

The compound she tested was Blue Cannatine from Troscriptions, a buccal troche combining methylene blue, CBD, caffeine, and nicotine. She took it the second day. Same room, same order of tasks, same eyes-closed-then-eyes-open recording protocol. One variable: a stimulant on board.

What does a QEEG brain map actually measure?

We put on a cap of electrodes, fill each site with conductive gel so the scalp signal reaches the amplifier, and record the electrical rhythms your cortex produces. Five minutes eyes closed, five minutes eyes open with your gaze fixed on one spot. That gives a resting baseline, your brain's idle, against age-matched population norms. If you want the full walkthrough of the procedure, I cover it in the QEEG brain mapping guide.

The map is a snapshot of how your circuits behave at rest. It tells you where the brain is over-allocating a frequency band and where it is under-recruiting one. Sleep trouble, anxiety, depression, ADHD, addiction patterns, PTSD: these show up in the data as specific spectral signatures, not as vague impressions. That is the value of mapping. You get a measurable picture of how your own brain may be getting in the way.

A note on test-retest. We do not expect a map to change meaningfully one day to the next. Your resting brain is rock solid the same two mornings in a row. So when something moves between baseline and nootropic, the substance moved it.

What did the attention test show before the nootropic?

Before we looked at brainwaves, she ran a continuous performance test twice: an attention measure and a stamina measure. The test has two sides. Attention is the gas pedal, clicking accurately on targets. Response control is the brake, withholding the click on the foil that follows a target. One is approach, the other is inhibitory tone.

Everything is age-matched against population curves. The mean is 100, with a 15-point standard deviation. Uncaffeinated, her full-scale attention score sat at 120, well above a standard deviation over average. Her visual and auditory scores spread apart slightly, which usually means a resource is being overused somewhere, though at that altitude it is hard to call.

Her visual reaction time was 157 on the test scale, and the raw speed was the standout. A late-teen athlete at peak conditioning registers visual information in roughly 70 milliseconds. The average twenty-year-old is closer to 90. The first 70 to 90 milliseconds is the signal arriving in cortex; everything after is the mind. Reacting at that floor is unusual fast. If you fast, manage stress, keep oxygenation high, you might shave into the 75-to-85 range. Hers was at the absurd end. Plenty of biohacking for intelligence points at exactly this kind of processing speed.

How did the nootropic change focus and stamina?

The troche sped her up. Full-scale attention climbed by 10 points, two-thirds of a standard deviation. That is not a practice effect and not a test-retest artifact; it is too large. Most of the gain was auditory. Visual attention rose about half a standard deviation, auditory rose a full 10 points. The compound filled an auditory bottleneck more than a visual one.

The brake side told the opposite story. Impulsivity went up, mostly because stamina collapsed. Her rock-solid baseline consistency tailed off toward the end of the task on both visual and auditory channels. Prudence stayed roughly the same, so this was not a strategy change; it was the raw resource fatiguing faster. Visual response control dropped from advantageous scores down to 104, still average, but no longer her standout.

This is the trade I see with stimulants generally. Speeding the system up biases the gas pedal up and the brake down. You get more attention and less inhibition in the same dose. If you struggle on the brake side at baseline, SMR neurofeedback trains exactly that inhibitory tone, and I unpack the speed-versus-control tension further in biohacking flow.

What did the brain maps reveal about mood and motivation?

Now the maps. Read alpha first. When alpha is high in the left front of the head, mood and approach motivation tend to sit low. This is the frontal alpha asymmetry literature, well-established as a marker of approach versus withdrawal. High left-frontal alpha looks like low engagement, a tendency to guard a resource rather than spend it.

On the nootropic, that left-frontal alpha dropped. The asymmetry shifted rightward, toward approach. In plain terms, the system flipped from protect-the-resource toward go-use-it. Jump in the car, go for the drive. Her mood signature looked better on the map, consistent with the engagement shift. If you want the deeper mechanism here, I wrote it up in decoding alpha waves and biohacking anxiety.

Why is auditory processing so sensitive in some brains?

The most interesting finding was not what the troche changed; it was what it did not. Behind both ears, over auditory cortex, the maps showed elevated theta and slow-wave activity in both recordings. The back right ran hot. The back right is where we plug the sensory world in, and when it runs hot I expect a particular profile: difficulty habituating to sound, sensory and social irritability, the princess-and-the-pea pattern where the car alarm two houses away gets in and stays in.

She confirmed it. Months living near a highway and still no habituation, even though the city brain next door tunes out a steady, non-changing roar within days. That is a built-in auditory quirk, present from the start rather than acquired, and it sat in the data regardless of the nootropic.

The troche made the auditory side worse over time. It shut down theta there but failed to bring the slow-wave delta up enough to wake the tissue, and her auditory stamina fatigued faster. So the stimulant that sharpened her overall focus also predicts more irritation with a roommate chewing, more trouble filtering competing voices on a group call. The sensory and social processing article covers this circuit in depth.

What is the overthinking marker on a brain map?

She mentioned a tendency to overanalyze. That usually lives at the anterior cingulate, the front midline. When the front midline runs hot in beta, I call it the OCD or CEO marker. It is the circuit behind songs stuck in your head and nail-biting, and also the circuit that builds companies and holds a vision with a steel grip. Hers showed the front-midline beta signature.

The nootropic unclenched it. Front-midline beta, the perseverative lock, dropped. The back-midline rumination signature dropped too. Both midline patterns went flat and flexible. Less stuck, less worried, less over-focused. The CBD content likely contributes to that relaxation alongside the stimulant lift. For the cortico-striatal mechanics underneath this, see biohacking OCD.

Reading the map as a system

Step back and the whole picture organized better on the nootropic. The top row of the analysis usually reflects metabolic issues, slow waves in the numerator. The middle row reflects executive function and filtering. The bottom row reflects anxiety. Across those rows the second map looked more broadly regulated.

There was a cost. Delta, the deep slow wave, dropped frontally. A lack of delta means the brain does not chill; it runs all-the-way-on or all-the-way-off. Fast waves decoupled a little in regions that normally run locked together, which buys flexibility but also explains the faster fatigue. More engaged, more flexible, less stuck, and burning the resource quicker. That is the full ledger, not just the upside.

What can you actually do with this?

A nootropic is one lever, and reading it against your own baseline tells you whether it helps you or fights your wiring. For this brain, the compound helped mood, engagement, and overall focus, and it cost auditory processing and stamina. Someone with a clean auditory cortex and weak inhibition would get a different ledger entirely. That is the point of mapping before you optimize.

The durable changes do not come from a troche. They come from training the circuits the map identifies. If the brake side is weak, you train inhibitory rhythms. If auditory cortex cannot habituate, you work on that integration directly. Neurofeedback is the tool for moving a resting baseline rather than borrowing a state for a few hours.

One more observation from the clinic that has stayed with me. The brains I have mapped in people recovering from COVID often look like they had a concussion. Same kind of slow-wave signature, same kind of disrupted regulation. That is clinical observation, not a controlled finding, and it is worth more study.

If you want to know why you cannot sleep, why you ruminate, why your focus fails on the brake side, the answer is in your own spectral data. Map first. Then decide what to change.

Full Transcript
hey rolled in my next health optimization journey i went and got my brain mapped not once but two times and that's because i wanted to compare how something which i will dive in in a little bit changes my brain activity so before i tell you all the details let me show you how it went so it all begins with putting on a red swim cap looking thing that has a bunch of holes in them now a really nice staff member will fill those holes with eeg gel so the electrodes could actually transmit the electricity what goes on in my brain onto the computer behind me which then eventually will get translated into a beautiful pdf with a bunch of colors of my brain showing up at certain parts now the way they read your my brain basically is sitting down closing your eyes for five minutes and then opening your eyes for five minutes looking at one spot on the wall and that's about it it measures your baseline how your brain is being active how your brain is behaving at rest so that was interesting but when it got even more interesting was when i went back the next day because take a look what i did it's in here so see this much put it over my gum and let's get blue all right so blue candidating is starting to hit meaning i'm starting to feel that rush of energy which is really good so let's take a look how it shows up in my brain yeah so the order of doing things was the same the only variable in this instance was the fact that my brain was sped up i took a nootropic beforehand i took a blue candidine nootropic substance which is a combination of methylene blue cbd caffeine and nicotine it's by the brand prescriptions which i've shared about previously that's one of the nootropics that i really feel a boost of cognitive functioning cognitive performance but either and i was really curious to see how it actually impacted my brain activity on a physiological level so i sat down well sit down you know nowadays sitting down is like zoom where dr andrew hill who is the founder of peak brain institute and he's also a functional neuroscientist coach in a brilliant fantastic wealth of knowledge so he told me a lot about my brain that i had no idea about and so besides reading my brain activity i had also completed both times an attention test and a stamina test how much my brain can actually pay attention to one monotone task at a time quite interesting and quite boring but surprisingly or not the troche boosted my focus quite a bit sped me up but there is a throwback kickback of it all so take a watch take a watch take a look there's two sides to this test as you see there's a tension and response control and attention is clicking successfully on the one response control is not clicking on the two or not slowing down for a two that follows a one for fret it's about the the moment of inhibitory tone if you will versus the gas pedal so left side here attention the gas pedal right side is the brakes okay this is all age matched everything we're doing is age matched against average population curves and the average is 100 that's the mean it's got a 15 point standard deviation so you're starting off so clean and uncaffeinated doing really well at 120 really high scores while well above a standard deviation but then you see your visual and your auditory or you know spreading apart a little bit which is a little unusual it means something's probably dragging this down a tiny bit but it's hard to tell you're so high above average that it could just be that you're overusing some of the resources but just the gross uh full-scale score you notice you went up by 10 points um so that's two-thirds of the standard deviation that's not a test retest effect at all that's not a practice effect uh also look what happened the visual crept up by half a standard deviation but the auditory by 10 points so this is an auditory change mostly okay so that means that my auditory skills are enhanced while i'm taking blue kennedy yeah slightly more than your visual skills are enhanced they both go up but it helps i think it helps sort of fill a bottleneck in your auditory better than filling a bottleneck in your visual slightly in some way and we see that in the brain as well by the way something interesting going on for you auditorily now on the impulsivity side or being disinhibited automatic reactive you it made you worse [Laughter] and it mostly because it killed your stamina everything else stayed the same pretty much but you got a tiniest bit more impulsive but you used to have this just like rock solid performance that is now tailing off towards the end with the same amount of prudence or carefulness so it's not a metacognitive strategy and roughly the same amount of consistency or raw resource that's really fatiguing the resources fatiguing it now an average level before a less than average level dramatically and the visual same thing you lost stamina yeah you also lost a little bit of prudence or carefulness your brain's a little more like squirrel you know it's a little harder yeah yeah it was a little dramatic yeah it's still average 104 but it used to be significant used to be performant you know advantageous scores for you way above average here so the troche makes you more impulsive but but less inattentive and mostly by speeding you up so it makes some sense that you're a little more impulsive if you're a little sped up right you know so it's a little more activated a little more on but that seems to bias the test towards the left side performing better the right side performing a little bit worse wow 157 you're really fast look at that visual reaction time adult humans who are athletes in their late teens at the peak of physical conditioning perceive information in about 70 milliseconds the average 20 year old proceeding information about 90 milliseconds okay anything you know 70 to 90 maybe you're super healthy about hacker oxygen you know you have lots of stress you fast whatever maybe you're in that 75 to 85 if you're if you're unusual the rest of this time is your mind the first of it's just like the information registering in your brain that's the first 70 to 90 milliseconds that means in something like 70 milliseconds you're reacting yeah to visual information that's ridiculous like 100 milliseconds that's yeah that's fast but 70 it's absurd all right i know you may be wondering where are the brain pictures they're coming right up i promise dr hill is going to dive into the brain activity in a minute but i want you to take your time bear with me because it's a lot of information quite comprehensive and very insightful and i will be adding some additional subtitles on the top to see which images are with eyes closed and which are with eyes open and which data analysis they are just so you understand it's it's a handful but take a look see something really quite um suggestive of changes in mood and motivation like an engagement thing left front half of the brain when alpha waves are high and i'll go through this in a second and teach you how to read these but generally when alpha waves are high in the left front of the head it means the mood isn't great specifically with like the approach versus the void so you can get features of mood not being ideal as mood but also get like a motivational stuff lack of organization and that's left front alpha sometimes for people so even if it didn't mean lack of that stuff initially the change would mean that your brain's in more of an approach mode because it shuts down and the alpha so it's like ooh what can i grab when i jump in my car and go for a drive i'm going to use the resource instead of maybe you know husband or protect the resource there's another thing going on it's behind the ears start there so we saw something in the performance that was specific and auditory we know something's a bit unusual and different in your auditory system and we see it on all the brain waves next to the ears just behind the ears auditory cortex so what i was assuming was a function of the back midline might actually be from the sides because laplacian does it over emphasizes sometimes where things are coming from so it could be creating a little echo so this could be purely auditory i mean the theta brain waves we're seeing are coming from the sides especially the back right and the back right is the place we plug the world into so i would expect generally from people to have a little bit of social and sensory irritability when the back right is a bit hot like you're probably a bit of a princess in the p with sensory information you can't ignore anything you hear the car alarm two houses away yes you're out of the package you're like oh it's scratching all day long you can't habituate simple things that everyone else can ignore i would guess you have a difficult time especially auditorily not letting things in everything that's auditory i would guess would get in yes especially even if at night i hear the highway not so far away it's just and it's really frustrating and that's not an especially dynamic sound i mean your brain people who live next to you know like the city thanks to highways very rapidly habituate to the non-changing level right it's been months and i can't get used to it it's a sensory thing um back right behind the ear you see it's there in both maps yes so it's not being changed by the trokie yeah not really that's other stuff has changed the theta is shut down so a little more on the more self-controlled but um actually but it's not actually changed appreciably in this way really the the troche woke you up so left front as i was saying has shifted you see it here you see it in the beta you see it in asymmetry right there the lines are all shifting it's a left front thing it's a motivation and a mood maybe an engagement for most people because al from the left front is neutral mood or or low engagement and shifting away from the shifting more to the right dropping this asymmetry means people feel like they want to like do stuff generally um but you see that actually the delta is a bit worse right there we saw the fatigue got worse in the performance so it does burn you out a little faster behind the auditory yeah in the auditory system i do i don't know if it might show up but i do have a tendency to overthink things and overanalyze things yeah that's usually the anterior cingulate that's which is what you're focusing on so if the anterior cingulates hot we call that the ocd or the ceo marker you know it's people that have songs in their head bite their nails but also build companies and hold visions with a steel trap in their mind and that's usually the front midline being hot in beta waves guess what there it is um so this can get in the way it doesn't have to and you're relaxed by the by the transcription a little bit yeah it actually unclenches that slight over focus perhaps um it makes the auditory worse it really shuts it really fatigues faster the auditory the delta waves the tissue is not waking up enough so the transcription will probably make the auditory processing stuff worse over time more irritated by your roommate chewing or whatever it is you know right or unless able to filter people speaking in group environments back we used to have group environments now it's group zooms like you'll hate people are speaking at once kind of thing yeah now but you see it does unclench the front midline which is good um it wakes up the frontal alpha waves which is about motivation look at all that alpha that's just gone this is your fatigue markers and then the the phase lag is timing lag this stuff usually goes down when you're tired and and the slow brain waves and then the front midline is locked when you're anxious or the or the perseverative piece the ceo a little little feature so even though you're not anxious with it does relax it and it also wakes you up so let celebrates get shut down fast waves get kind of decoupled a little bit in places where they're typically running at a high speed so you get a little more flexible um so you see the front midline the back midline both the front midline is yeah uh perseverative the back midline is ruminative they both dropped really nicely beautifully in fact just gone look really flexible yeah yeah yeah the the troche is very look very flexible internally and less stuck less worried less anxious less you know over focused in this one and your mood looks better the left front alpha the mood you know and the auditory processing looks better by the ear so yeah and that wakes you up as well because lack of delta means your brain doesn't chill you know it's like all the way on or all the way off all the way on you know that's the black of delta and this actually helps the kind of like relax a little bit so we can let go of the other frequencies a tiny bit and hearing ratio uh we often see executive function things and thetas and betas this is clearly social and sensory it's vestibular it's something interesting it's very much auditory for you is the only thing you appear to have some built-in auditory processing quirk um probably from being you know built this way or born this way right no idea why but it's really helped quite a lot with the uh stimulant yeah it's so all of that right ear blurb yeah it wakes up it shuts down the theta it also brings up the slow brain wave delta's in the numerator here this usually metabolic issues the top row the middle row is usually executive and filtering the bottom row is usually anxiety so it just looks better regulated broadly i mean broadly with this uh change and again we don't expect a map to change day after day yeah we rock solid the same time you know two days in a row okay i know that's a lot but my brain is going to be different than your brain and jane's brain is going to be different than john's brain so if you want to find out what your brain is like why you perhaps can't sleep why you are ruminating why you're anxious why you're depressed perhaps are you having ptsd this all shows up in your brain in fact dr hill told me that he noticed the people who had coveted their brain looked like they had a concussion so i'll let you ruminate on that because it's fascinating all right that's it for this video if you have any questions you can reach out to me over on instagram my handle is byline by claudia if you're watching this here you probably are already there or on my website which you can find in my instagram bio so yeah that's it if you have any questions let me know i'm happy to answer them or if i can't i will point you to the right person who can so in the meantime stay healthy stay resilient keep up the amazing things you're doing and i will talk to you soon bye